Intracytoplasmic Sperm Injection (ICSI)

Overview

Intracytoplasmic sperm injection (ICSI) is an advanced fertility treatment used in conjunction with in vitro fertilization (IVF). During ICSI, a single sperm is directly injected into an egg to facilitate fertilization. This technique is particularly beneficial for couples dealing with male infertility issues, such as low sperm count or poor sperm quality. ICSI has revolutionized assisted reproductive technology and offers hope to many aspiring parents.

About Intracytoplasmic Sperm Injection (ICSI)

Intracytoplasmic sperm injection (ICSI) is an in vitro fertilization (IVF) procedure where a single sperm cell is directly injected into the cytoplasm of an egg. This technique is used to prepare gametes for obtaining embryos that can be transferred to a maternal uterus. ICSI is particularly helpful for people experiencing male infertility due to issues like low sperm count, poor sperm quality, or blockages in the male reproductive system.

What is ICSI? 

Intracytoplasmic sperm injection (ICSI) is a groundbreaking assisted reproductive technique that has transformed fertility treatments. In the context of in vitro fertilization (IVF), ICSI involves the precise injection of a single sperm directly into an egg. This microsurgical procedure bypasses natural barriers and facilitates fertilization, even when male infertility factors—such as low sperm count, poor motility, or abnormal morphology—are present. ICSI offers hope to couples struggling with conception challenges, allowing them to achieve parenthood. The delicate precision required for ICSI, along with advancements in micromanipulation technology, has significantly improved success rates in assisted reproduction. As a result, ICSI has become a cornerstone of modern fertility clinics, empowering individuals and couples on their journey toward building a family.

Who is a Good Candidate for ICSI?

Intracytoplasmic Sperm Injection (ICSI) is a powerful tool in assisted reproductive technology, particularly beneficial for couples facing infertility challenges. Here are candidates for whom ICSI might be recommended:

Male Infertility

• Low Sperm Count: Men with severely low sperm counts can benefit from ICSI. Unlike traditional IVF, which requires millions of viable sperm, ICSI allows successful fertilization with just one sperm.

• Poor Sperm Motility: When sperm struggle to swim effectively, ICSI ensures direct injection into the egg, bypassing motility issues.

• Sperm Development Problems: Abnormal sperm shape or development can be overcome through ICSI.

• Blockages: If a vasectomy or other blockage prevents sperm from being ejaculated, ICSI can retrieve sperm from the testicles or epididymis.

Female Infertility

• Few Viable Eggs: ICSI increases conception chances for women with limited viable eggs.

• Unexplained Infertility: When the cause remains unclear, ICSI offers a targeted approach.

• Genetic Disorders: If there's a risk of passing on genetic disorders, ICSI can help select healthy embryos.

Intracytoplasmic Sperm Injection (ICSI) Procedure

ICSI Process 

• Ovarian Stimulation: Hormonal medications stimulate multiple ovarian follicles to mature simultaneously. These yield more eggs for fertilization and enhance pregnancy chances. Ovarian stimulation also prevents spontaneous ovulation, which is crucial for IVF success.

• Follicular Puncture: Once follicles are mature, a minor surgical procedure collects the eggs. A skilled clinician uses ultrasound guidance to aspirate the follicles.

• Oocyte Denudation: The protective layer around the egg (cumulus cells) is removed. This exposes the egg's surface for fertilization.

• Sperm Collection & Preparation: Sperm are collected from the male partner or a donor. The best sperm are selected based on morphology and motility. These sperm are prepared for injection.

• Oocyte Fertilization (ICSI): Using a micropipette, a single sperm is injected directly into the egg's cytoplasm. This precise technique ensures fertilization even with minimal sperm count or motility.

• Embryo Culture: Fertilized eggs (now embryos) are cultured in the lab for 1 to 5 days. Embryos develop and multiply.

• Embryo Transfer: A healthy embryo is selected for transfer to the woman's uterus. The goal is successful implantation and pregnancy.

• Embryo Vitrification: Any remaining viable embryos can be frozen (vitrified) for future use.

The Risks & Benefits of Doing ICSI

Benefits of ICSI

• Enhanced Fertilization Rate: Compared to traditional IVF, ICSI significantly improves the chances of fertilization. By directly injecting a single sperm into an egg, ICSI bypasses barriers and increases the number of viable embryos available for transfer or freezing.

• Male Factor Infertility: ICSI is a lifeline for men with low sperm count, poor sperm quality, or ejaculation issues. It allows them to use their own sperm to father a child, eliminating the need for a sperm donor.

• Precision and Success: ICSI's microsurgical precision ensures that even minimal sperm counts can lead to successful fertilization. It's a game-changer for couples striving to conceive.

Risks of ICSI

• Egg Damage: During the ICSI procedure, there's a small risk of damaging some or all of the eggs due to needle penetration.

• Failed Fertilization: Despite precise sperm injection, there's a possibility that an egg may not fertilize successfully.

• Embryo Development Issues: An embryo might stop developing either in the lab or after transfer.

Intracytoplasmic Sperm Injection (ICSI) in Iran

Equipped hospitals, and advanced specialized centers with experienced doctors and specialists are available in all medical treatment areas in Iran. Also, good hotels and entertainment centers have made Iran an appropriate choice for patients who are struggling with getting pregnant and need ICSI treatment.

ICSI Success Rates in Iran 

Intracytoplasmic Sperm Injection (ICSI) in Iran boasts a competitive success rate of around 60%. This achievement places Iran on the international map as an appealing destination for couples seeking ICSI treatment. The high success rates are attributed to Iranian clinics' comprehensive approach, state-of-the-art technology, and skilled medical professionals. Factors such as patient age, the cause of infertility, and the quality of sperm and eggs play a crucial role in determining ICSI success. Couples considering ICSI can find hope and expert care in Iran's fertility clinics.

ICSI Cost in Iran 

Intracytoplasmic Sperm Injection (ICSI) treatment in Iran is an attractive option for couples seeking fertility solutions. The cost varies across cities, making it accessible to a wide range of patients. Some of the expenses include:

• Consultation: Initial consultation with a fertility specialist.

• ICSI Laboratory Costs: Includes the precise sperm injection procedure.

• Physician and Anesthesiologist Fees: Professional services during the treatment.

• Stimulant Drugs: Medications to enhance egg production.

• Laboratory Tests and Research: Comprehensive assessments.

The cost of ICSI treatment in Iran ranges from around 3000-4000 USD, depending on the location and specific clinic. Compared to other countries, this pricing is remarkably affordable. Beyond the medical benefits, Iran also offers a rich cultural experience, making it a fascinating destination for those seeking both fertility treatment and memorable moments.